Hill et al 1975 mass spectrometry in cancer research 243 employed ms to characterize the microsomal metabolism of the nitrosoureas the metabolic product of bcnu was 13bis 2 chloroethyl urea the products of ccnu and methyl ccnu were ringhydroxylated derivatives. Researchers use imaging techniques such as mass tag cellular bar coding using imaging ms via maldi spectrometry combines chemical labeling in cancer tissue specimens to map proteomic data with conventionally stained histopathology sections as with biofluid examination researchers must overcome problems with complex matrices masking proteins of low abundance. Mass spectrometry imaging has already had a substantial impact in cancer research uncovering biomolecular changes associated with disease progression diagnosis and prognosis many new approaches are incorporating the use of readily available formalin fixed paraffin embedded cancer tissues from pathology centers including tissue blocks biopsy specimens and tumor microarrays it is also increasingly used in drug formulation development as an inexpensive method to determine the . Her research interests evolve at the interface between technology development and biology with focus on exploring the molecular mechanisms of breast cancer cell cycle regulation by using mass spectrometry based systems biology approaches her laboratory develops microfluidic and proteomic technologies for investigating the pathways that enable cancer cells to bypass tightly regulated
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